Interstate 57 is closed in both directions from Interstate 55 to the Illinois state line, according to the Missouri Department of Transportation.

“Both directions are closed and there is a large-scale cleanup underway as well as continuing major-crash fatality scene investigation,” the Missouri Department of Public Safety tweeted, adding the crash involved “several tractor trailers.”

Charleston’s Department of Public Safety Director Robert Hearnes told CNN affiliate KFVS that he is “not sure of the total injuries. We do have fatalities,” adding that “unfortunately they are trying to extricate some of the fatalities.”

This is a developing story and will be updated.

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